What is the safest way to get from Cancun airport to Playa del Carmen?

Fuhr

Hire a private transport van before you arrive. It's also the quickest.

Ambistoma

Safe from what? Motor accidents? Bandits? Getting lost? Your hotel might offer private transportation. Otherwise, if you don't find anything you like at the airport, I would just take the public bus to the Cancun station and then transfer to a bus to PdC, since there are lots of them.

Brando

Everything will depend on what you want to do next, for example, if you want to move around the city, my recommendation is that you rent a car, but if you want to go to the airport when you arrive at the airport then I recommend service transportation. One of the best option to book Cancun transportation is with eTransfers.

megalomaniac

Rent an M1 Abrams. Don't leave home without it. Actually I'm not even kidding all that much. I wouldn't want to travel in Mexico these days without an armored vehicle (and even then I'd be cautious).